Toxicity of Chemical Mixtures: Risk, Hazard and Exposure Assessment

The International Akademie Fresenius MIXTOX Conference will provide you with the opportunity to discuss current regulatory changes and risk assessment and management methods of chemical mixtures. Bringing together relevant regulaotry institutions, as well as stakeholders from industry and the research field, it will provide updates on crucial topics, such as implementing a mixture risk assessment, current EU projects and will be relevant to those working within the framework of the REACH Regulation and Regulation (EC) No 1107/2009 for Plant Protection.

Guaranteed realization
12.06. — 13.06.2023
Online Conference
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OverviewProgrammeSpeakersVenuePrices & Services

Overview

Highlights

  • EFSA’s scientific strategy on mixtures risk assessment and the main outcomes of the EFSA ONE Conference
  • RIVM on the RACEMiC Roadmap for Combined Exposure to Multiple Chemicals
  • Member State view: Ecotoxicological risk assessment of mixtures from Ctgb
  • REACH and Mixture Assessment Factor (MAF)
  • The HBM4EU-SPECIMEn study
  • EFSA-RIVM cooperation on software for human mixture risk assessment
  • EFSA’s standard approach on mixtures for aquatic organisms: A component-based risk assessments and the use of the RQmix approach (RQ = PEC/RAC) as a better alternative
  • Plant protection: Aggregate exposure assessment for dietary and non-dietary exposure

Who should attend this conference?

Professionals working in the fields of:

  • Toxicology
  • Hazard, exposure and risk assessment for human health
  • Modelling
  • Regulatory affairs
  • Registration and authorisation
  • Scientific advisory
  • Product safety

Sectors that should take part:

  • Agrochemical industry
  • Biocidal products producers
  • Chemical industry
  • Research institutes
  • Authorities
  • Scientific consultancies in the area of toxicology
  • Professional associations
  • NGOs

Picture Credit: © Irochka - Fotolia.com

 

Programme

Monday, 12 June 2023

PLEASE NOTE: The indicated times refer to Central European Time CEST. For further time zones, please view here.



Morning Session | 09:30 – 13:00 CEST
09:30
Welcome address by the organisers and the Chairs

Stephanie Melching-Kollmuss, BASF/CropLife Europe Working Group on Cumulative Risk Assessment, Germany
Martin Wilks, Swiss Centre for Applied Human Toxicology, Switzerland

Mixture Assessment in Europe – Strategies and a Way Forward
09:40
The Chemicals Strategy for Sustainability (CSS) and Mixtures

Finn Pedersen, European Commission, Belgium

10:15
EFSA’s scientific strategy on mixtures risk assessment and the main outcomes of the EFSA ONE Conference

Bruno Dujardin, European Food Safety Authority (EFSA), Italy

10:50
REACH and Mixture Assessment Factor (MAF)

Nathalie Vallotton, Dow Europe, Switzerland

11:25
Coffee break
Risk Assessment of Chemical Mixtures: Human Health
11:50
Development of a roadmap for action on risk assessment of combined exposure to multiple chemicals
  • Need for a roadmap on mixture risk assessment
  • Current state of play on mixture risk assessment
  • Project proposal to fill gaps in available data, methods and tools

Esther de Jong, National Institute for Public Health and the Environment (RIVM), The Netherlands

12:25
Real-life mixtures - activities under the PARC Project

Amélie Crépet, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), France

13:00
Lunch break


Afternoon Session | 14:00 – 16:40 CEST
14:00
EFSA-RIVM cooperation on software for human mixture risk assessment
  • The Monte Carlo Risk Assessment software (MCRA)
  • How the software might be used by European regulators to fulfil regulatory requirements
  • How the software might be used by study owners of human biomonitoring data in PARC
  • Training activities

Jacob van Klaveren, National Institute for Public Health and the Environment (RIVM), The Netherlands

14:35
The HBM4EU-SPECIMEn study and the use of ist data to study mixture exposure

Jelle Vlaanderen, Utrecht University, The Netherlands

15:10
Coffee break
15:30
Aggregate exposure assessment for dietary and non-dietary exposure

Marc Kennedy, Fera Science, United Kingdom

16:05
Data-driven alternatives to MAF – a case study of plant protection products
  • Establishment of triggers for higher tier in vitro testing
  • Comparative testing of pesticides and plant protection products
  • Derivation of toxicological threshold values for plant protection products

Denise Bloch, Federal Institute for Risk Assessment (BfR), Germany

16:40
End of the first day


Tuesday, 13 June 2023

PLEASE NOTE: The indicated times refer to Central European Time CEST. For further time zones, please view here.



Morning Session | 09:30 – 12:00 CEST
09:30
Brief address by the Chairs

Stephanie Melching-Kollmuss, BASF/CropLife Europe Working Group on Cumulative Risk Assessment, Germany
Martin Wilks, Swiss Centre for Applied Human Toxicology, Switzerland

Scientific Reappraisal of Mixtures
09:45
Scientific view on mixture assessment of chemicals: A systematic review and quantitative reappraisal of ten years of mixture studies

Olwenn Martin, University College London, United Kingdom

Ecotoxicological Risk Assessment of Chemical Mixtures
10:20
Member State view: Ecotoxicological risk assessment of mixtures in plant protection products
  • Past, present, future
  • From single formulation to landscape issues

Mathilde Zorn, Board for the Authorisation of Plant Protection Products and Biocides (Ctgb), The Netherlands

10:55
Industry view on ecotoxicological risk assessment of chemical mixtures

Arnd Weyers, Bayer Crop Science, Germany

12:00
Lunch break


Afternoon Session | 12:45 – 14:00 CEST
12:45
EFSA’s standard approach on mixtures for aquatic Organisms: A component-based risk assessments and the use of the RQmix approach (RQ = PEC/RAC) as a better alternative
  • Review of the EFSA assessment scheme for agrochemical combination products for aquatic organisms
  • Significance of product data for the evaluation of risk for mixtures and the definition of formulation endpoints
  • Proposal of an efficient and meaningful assessment scheme and the interpretation of data for the formulated product

Gero Eck, Exponent International, Switzerland

13:20
Environmental risk of chemical mixtures – relevance and current approaches in retrospective and prospective risk assessment
  • Concepts
  • Mixture risk in surface waters (chemical and biological monitoring)
  • Approaches in prospective risk assessment (MCR, MAF)

Marion Junghans, Centre Ecotox, Switzerland

14:00
End of the conference

Speakers

Name

Company

Denise Bloch

Federal Institute for Risk Assessment (BfR), Germany

Denise Bloch heads the Junior Research Group “New Approach Methodology (NAM)-based assessment of mixtures” at the German Federal Institute for Risk Assessment (BfR). Her research is focused on improving the human health risk assessment of mixtures by the application of alternatives to animal testing. In the past, she has worked as a regulator in the zonal authorisation of plant protection products at BfR (DE), conducted research on active transport inhibition at the Helmholtz Centre for Environmental Research in Leipzig (DE) and has studied biogeochemistry at ETH Zurich (CH).

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Crépet

Amélie Crépet

French Agency for Food, Environmental and Occupational Health and Safety (ANSES), France

Amélie Crépet works for the French Competent Authority ANSES, where she coordinates experts groups on mixture and exposome. At the European level, Amélie coordinated work package or tasks in projects on mixture risk assessment (EUROMIX 2015-2019), on biomonitoring data (HBM4EU 2017-2021) and children chemical exposome (ATHLETE, 2020-2024). She participated actively to construct the PARC project (2021-2028), and she is co-leader of the task on integrative exposure and risk assessment. She was involved in the EFSA expert group on scientific criteria to group substances in mixtures and the one of WHO in 2019.

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Dujardin

Bruno Dujardin

European Food Safety Authority (EFSA), Italy

Bruno Dujardin is a senior scientific officer at the European Food Safety Authority (EFSA), where he has gained extensive experience in the regulatory risk assessment of chemicals. Recently, he took up a new role as team leader within the Methodology and Scientific Support unit. His team provides transversal support on exposure assessment, statistical data analysis and modelling. Within this capacity, Bruno is also responsible for steering the implementation of more holistic approaches that account for combined exposure to multiple chemicals.

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Eck

Gero Eck

Exponent International, Switzerland

Gero Eck is currently heading the European ecotoxicology team at Exponent International. In his previous roles as a regulatory ecotoxicologists he was working for industry and other consultants

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Marion Junghans

Centre Ecotox (Eawag), Switzerland

Marion Junghans is the Team Leader Risk Assessment at the Swiss Centre Ecotox. Her areas of expertise include the risk assessment for micropollutants in water, the prediction of mixture toxicity and OECD test methods in the fields of aquatic ecotoxicology, biological degradability and environmental behaviour, as well as risk communication.

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Kennedy

Marc Kennedy

Fera Science, United Kingdom

Marc Kennedy joined the Central Science Laboratory (now Fera Science Ltd) in 2006 and has worked primarily on probabilistic models for pesticide intakes from dietary and occupational routes. He has a PhD in statistics and has worked at the universities of Nottingham and Sheffield and the National Institute of Statistical Sciences. Marc has also contributed to risk modelling software BREAM, BREAM2, and BROWSE for bystanders, residents, operators, and workers exposure and developed aggregate exposure models in the EU ACROPOLIS and EUROMIX projects.

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Olwenn Martin

University College London, United Kingdom

Olwenn Martin is an Associate Professor in Health and Environment at University College London. She has an interdisciplinary background in chemistry, environmental sciences, environmental decision-making and development management. She was one of the earliest adopters of applying the principles of evidence-based medicine to environmental health and toxicology, including systematic review and meta-analysis and socio-economic analyses. She has specific interests in endocrine disruption and mixture effects.

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Melching-Kollmuss

Stephanie Melching-Kollmuss

BASF, Germany

Stephanie Melching-Kollmuss has been working in the field of regulatory toxicology for chemicals and plant protection products for over 20 years, for more than 15 years at BASF SE. Her special interest is in mixture toxicity and endocrine disruption. Stephanie was involved in two Cefic LRI projects: “Combined low-dose exposures to anti-androgenic substances” and “Developing a quantitative AOP for liver-mediated thyroid modulation after prenatal exposure to a xenobiotic compound in the rat”.

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Finn Pedersen

European Commission, Belgium

Finn Pedersen is Seconded National Expert at the European Commission. He is currently working on the revision of REACH including the use of MAF in REACH. He has previously worked as Chief Advisor for chemicals policy activities, incl. REACH, CLP, biocides, cosmetics, nanomaterials, international conventions, OECD collaboration for the Danish Ministry of Environment and Food.

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Vallotton

Nathalie Vallotton

Dow Europe, Switzerland

Nathalie Vallotton is a Global Regulatory Environmental Science Manager at Dow Europe. She is member of the ECETOC task force on “Persistent chemicals and water resources protection” and is a member of the Cefic Persistence Issue Team.

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Jelle Vllaanderen

Utrecht University, The Netherlands

Jelle Vlaanderen is an Associate Professor at the University of Utrecht, with a keen research interest in, epidemiology, including epidemiology of environmental and molecular epidemiology. He has previously held a position as postdoctoral fellow at IARC the International Agency for Research on Cancer.

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Weyers

Arnd Weyers

Bayer Crop Science, Germany

Arnd Weyers is an Ecotoxicology Expert (terrestrial vertebrates) at Bayer CropScience with over 10 years of experience in this field. He has previously held positions as Head of Laboratory at Currenta and Head of the BUA-Office Ecotoxicology at Dresden University of Technology.

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Wilks

Martin Wilks

Swiss Centre for Applied Human Toxicology, Switzerland

Martin Wilks is a Medical Toxicologist and risk assessment expert with more than 30 years of experience in academia, industry and the health service. He is Director of the Swiss Centre for Applied Human Toxicology (SCAHT) and Adjunct Professor at the University of Geneva and the University of Basel. He is a EUROTOX Registered Toxicologist, a Fellow of the Royal College of Physicians of Edinburgh, Secretary-General of EUROTOX and President-elect of the International Union of Toxicology (IUTOX).

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Mathilde Zorn

Board for the Authorisation of Plant Protection Products and Biocides (Ctgb), The Netherlands

Mathilde Zorn is a member of the ecotoxicology team of the Dutch board for the authorization of Plant Protection Products and Biocides (CTGB). She has more than 15 years of experience in the ecotoxicological risk assessment of plant protection products with special interest in the areas of birds and mammals, soil organisms and combination/formulation toxicology.

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de Jong

Esther de Jong

National Institute for Public Health and the Environment (RIVM), The Netherlands

Esther de Jong is a risk assessor and project manager at the Dutch National Institute for Public Health and the Environment (RIVM). She is a European Registered Toxicologist (ERT) who has been working in the field of plant protection products for over a decade.

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van Klaveren

Jacob van Klaveren

National Institute for Public Health and the Environment (RIVM), The Netherlands

Jacob van Klaveren coordinated the European funded projects ACROPOLIS and EuroMix aiming to improve combined exposure to multiple chemicals in Europe. Since 2015, Jacob has been coordinating the EFSA-RIVM partnership on mixtures of pesticides. From January 2020 onwards he has been participating in the interim management board of the Horizon Europe Partnership for the Assessment of the Risk from Chemicals (PARC) and has been responsible for coordinating the work programme innovation in regulatory risk assessment.

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Venue

Online Conference
This conference is going to be held online.
You can reach us directly at:
Phone : +49 231 75896-50
Email: info@akademie-fresenius.de
www.akademie-fresenius.de

Prices & Services

Participation Fee: € 1,195.00 plus VAT.

The registration fee includes the following benefits:

  • Participation in the Online Event
  • Event Documentation (available via download from our website)
  • Certificate of attendance

Representatives of an authority or a public university are therefore eligible for a reduced fee of € 695.00 plus VAT per person (please provide evidence). The reduced fee cannot be combined with other rebates.

Group Reductions
For joint bookings received from one company we grant a 15% discount from the third participant onwards.

Terms of Cancellation / Book without Risk
You can cancel your participation in our online events free of charge and without giving reasons in writing up to 1 week before the start of the event. In the case of later cancellations and non-login to the online event, no participation fees can be refunded.
In this case, however, you will receive access to the documentation after the event.
You can name a substitute participant free of charge at any time.

Anne Möller

Your Contact

Anne Möller
Programme and conceptual design

+49 231 75896-84
amoeller@akademie-fresenius.de

Anne Möller

Your Contact

Anne Möller
Programme and conceptual design

+49 231 75896-84
amoeller@akademie-fresenius.de

Anne Möller

Your Contact

Anne Möller
Programme and conceptual design

+49 231 75896-84
amoeller@akademie-fresenius.de

Danielle Sörries

Your Contact

Danielle Sörries
Organisation and participant management

+49 231 75896-74
dsoerries@akademie-fresenius.de

Danielle Sörries

Your Contact

Danielle Sörries
Organisation and participant management

+49 231 75896-74
dsoerries@akademie-fresenius.de

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Display / Supplement

Present your Company at the Event.

You can personally present your products and services directly to your specified target group. We are happy to provide you with further information on our range of available options – from displaying company information at the reception counter to presenting your company with an exhibition stand.

We would be pleased to assist you personally:

Monika Stratmann

Monika Stratmann
Phone: +49 231 75896-48
info@akademie-fresenius.de

Press Contact

We offer journalists and editors a platform where they can get in touch with the experts.

If you are the editor of a specialist publication and interested in a press pass or media partnership, please contact us well in advance. We are happy to advise you.


Please contact us:

Katharina Geraridis

Katharina Geraridis
Phone: +49 231 75896-67
presse@akademie-fresenius.de