2nd International Akademie Fresenius Conference "Regulatory Toxicology of Active Substances in Plant Protection Products"+++ONLINE CONFERENCE+++

16 Mar - 17 Mar 2022, Online Conference | Die Akademie Fresenius GmbH

2nd International Akademie Fresenius Conference "Regulatory Toxicology of Active Substances in Plant Protection Products"+++ONLINE CONFERENCE+++

Overview Programme Speakers Venue Prices & Services

Overview

Highlights

Metabolites 

  • EFSA’s Scientific Opinion on testing and interpretation of in vitro comparative metabolism studies
  • OECD Guidance on residue definition – toxicological considerations
  • Use and implementation of EFSA’s templates for submission of in silico information on metabolites and impurities

Cumulative assessment

  • EFSA’s Guidance on Scientific criteria for grouping chemicals into assessment groups (MixTox2)
  • Cumulative assessment groups – industries’ work

Evaluation of pesticides

  • Historical control data (HCD) and its use for evaluation of studies results

Genotoxicity

  • EFSA’s Guidance on aneugenicity assessment
  • Industry perspective on changes in the Guidance on groundwater metabolites as regards genotoxicity

New approach methodologies

  • EFSA’s Scientific Opinion on developmental neurotoxicity (DNT)
  • EU-ToxRisk experience as regards chemical read-across
  • EFSA's project on read-across and how to take read-across further into risk assessment

Who do you meet?

Groups that should take part:

Managing directors, boards of directors, members of supervisory boards, managers and scientists in the field of:

  • Toxicology
  • Registration
  • Marketing & distribution
  • Human exposure & risk assessment
  • Research & development
  • Product stewardship & responsible care
  • Human/Consumer safety – crop protection

Sectors that should take part:

  • Agrochemical industry
  • Research institutes, authorities (agricultural inspection offices, registration and control authorities)
  • Professional associations
  • Contract laboratories

Picture credit: © noerenberg

Programme

PLEASE NOTE: The indicated times refer to Central European Time CET.

For further time zones, please view here.

Wednesday, 16 March 2022

Afternoon Session 12:45 – 16:45 CET

Welcome address by Akademie Fresenius and introduction by the Chairs

Tamara Coja, Austrian Agency for Health and Food Safety (AGES), Austria

Susanne Hougaard Bennekou, Technical University of Denmark (DTU), Denmark

Metabolites

EFSA Scientific Opinion on testing and interpretation of in vitro comparative metabolism studies
Olavi Pelkonen, University of Oulu, Finland

OECD Guidance on residue definition – toxicological considerations
Monika Kemény, BASF, Germany

EFSA templates for submission of in silico information on metabolites and impurities
Juan Parra Morte, European Food Safety Authority (EFSA), Italy

Cumulative assessment

Guidance on Scientific criteria for grouping chemicals into assessment groups (MixTox2)
Kyriaki Machera, Benaki Phytopathological Institute (BPI), Greece

Cumulative assessment groups – industries’ work

  • Relevant and stringent criteria for grouping of compounds
  • Exposure-based prioritisation for retrospective and prospective cumulative risk assessments
  • Views on aggregate cumulative assessments

Stephanie Melching-Kollmuss, BASF, Germany

PLEASE NOTE: The indicated times refer to Central European Time CET.

For further time zones, please view here.

Thursday, 17 March 2022

Morning Session 9:00 – 13:30 CET

Evaluation of pesticides

Historical control data (HCD) and its use for evaluation of studies results

  • 40 years of discussions in the scientific community
  • Coherent theoretical considerations and different practical implementations
  • Effort to bring together relevant stakeholders and set the scene for common understanding - an EFSA project

Tamara Coja, Austrian Agency for Health and Food Safety (AGES), Austria

Genotoxicity

EFSA guidance on aneugenicity assessment
Diane Benford, Vice-Chair of the EFSA Scientific Committee

Industry perspective on changes in the Guidance on groundwater metabolites as regards genotoxicity

  • Changes implemented in the revised guidance and their impact on metabolite assessment
  • Where does the test strategy for groundwater metabolites deviate from other guidance?
  • Do we still need an in vitro mammalian gene mutation assay as part of the test battery?

Krista Meurer, BASF, Germany

New approach methodologies

EFSA Scientific Opinion on developmental neurotoxicity (DNT)
Martin Paparella, Medical University of Innsbruck, Austria

EU-ToxRisk experience as regards chemical read-across

  • Use of mechanistic information from new approach methods to support similarity assessment within read-across approaches
  • Testing strategy informed by adverse outcome pathways
  • Derivation of a point of departure for risk assessment using IVIVE (in vitro to in vivo extrapolation) and PBK (physiologically based kinetic) modelling

Sylvia Escher, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Germany

EFSA's project on read-across using their pesticide database and how to take read-across further into risk assessment
George Kass, European Food Safety Authority (EFSA), Italy

Speakers

Name

Company

Benford

Diane Benford

A Vice-Chair of the EFSA Scientific Committee

Diane Benford is a Toxicologist and retired as a Head of a team responsible for risk assessment of all types of chemicals in food from the UK Food Standards Agency (FSA) in 2017. She joined the EFSA CONTAM Panel in 2005 and was also the Chair from 2012 to 2015. Since 2015 she has been a Member and Vice-Chair of the EFSA Scientific Committee.

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Bennekou

Susanne Hougaard Bennekou

Technical University of Denmark (DTU), Denmark

Susanne Hougaard Bennekou joined the Division of Risk Assessment and Nutrition at the National Food Institute of the Technical University of Denmark (DTU) as a Senior Advisor in toxicology in 2019. She has previously worked as a Senior Advisor in the Pesticide Division of the Danish EPA. She was the Vice-Chair of the EFSA PPR Panel and since 2018 she has been a Vice-Chair of the EFSA Scientific Committee.

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Coja

Tamara Coja

Austrian Agency for Health and Food Safety (AGES), Austria

Tamara Coja is a Biologist and has been working as a Senior Regulatory Toxicologist at the Austrian Agency for Health and Food Safety (AGES) in Vienna. Since 2007 she has been involved in toxicological evaluation of pesticides. Her special regulatory interest is in toxicity of metabolites in residues of plant and animal origin and in groundwater. Since 2018 she is a member of the EFSA PPR Panel and joined working groups.

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Sylvia Escher

Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Germany

Sylvia Escher is a Chemist and trained Toxicologist and the Head of the Department of In-silico Toxicology at the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM). The focus of her work the use of alternative methods such as QSAR models and grouping approaches in safety and risk assessment. This include the development and maintenance of toxicological databases. For some years now, the integration of new methods in human risk assessment, such as those developed in the EUTOXRISK and EXITOX project, has increasingly become the focus of their work. In this context ITEM is developing workflows to integrate omic data as well as PBK models, specialized on uptake and distribution of airborne compounds.

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Kass

George Kass

European Food Safety Authority (EFSA), Italy

George Kass is a Toxicologist. He gained his PhD from the Karolinska Institute in Stockholm, then in 1994, he became Associate Professor and subsequently Full Professor of Toxicology at the University of Surrey, UK. His research focused on the molecular mechanisms of drug toxicity and on liver injury. In 2009 he moved to EFSA where his work focuses on the development of novel approaches and the impact of new technologies on chemical risk assessment. He maintains visiting posts with the University of Surrey and the National University of Ireland in Galway.

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Monika Kemény

BASF, Germany

Monika Kemény is a Certified Toxicologist and has been a Regulatory Toxicologist at BASF, Germany, since 2006. Before joining BASF she has worked for the DFG Senate Commission on Food Safety (SKLM) since 2002.

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Kyriaki Machera

Benaki Phytopathological Institute (BPI), Greece

Kyriaki Machera has been the Head of the Laboratory of Pesticides’ Toxicology at the Benaki Phytopathological Institute, Greece, since 1990, became the Head of the Department of Pesticides’ Control and Phytopharmacy in 2005 and since 2010 she has been the Director General. Her scientific activities involve both research and regulatory toxicology with focus on hazard identification and risk assessment of plant protection and biocidal products, as well as identification of the toxicological profile of bioactive natural compounds. She has coordinated and participated in a number of co-funded projects by the European Commission, the European Food Safety Authority and other public sources. She has been a member of the EFSA PPR Panel for three mandates, the first one was at 2003-2006 and the last at 2015-2018 and since 2019 she is a member of the EFSA Scientific Committee and other EFSA Working Groups. She is also a member of the European Partnership for Chemical’s Risk Assessment (PARC).

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Melching-Kollmuss

Stephanie Melching-Kollmuss

BASF, Germany

Stephanie Melching-Kollmuss has been working as European and Global Regulatory Toxicologist for agrochemicals at BASF since 2006. Her main research interest is endocrine disruption and combined toxicity assessment and she continues to be involved in ECETOC and Cefic LRI projects on these topics. She was member of the Scientific Advisory Board of the European EuroMix project. Stephanie chairs the Cumulative Risk Assessment Subgroup of Crop Life Europe and has published in the area of mixture toxicity and cumulative risk assessment.

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Meurer

Krista Meurer

BASF, Germany

Krista Meurer has been a Regulatory Toxicologist for Crop Protection at BASF since 2008. In support of European and global registrations, she is responsible for human health risk assessment for pesticide products and active substances. Based on 10 years experience as a Study Director in contract research Krista has a special interest in genetic toxicology testing and is a member of the CropLife Europe genotoxicity expert group as well as the Health and Environmental Sciences Institute (HESI) Genetic Technical Committee (GTTC).

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Paparella

Martin Paparella

Medical University of Innsbruck, Austria

Martin Paparella is a Regulatory Toxicologist at the Institute of Medical Biochemistry of the Medical University Innsbruck where he is involved in the development and standardisation of regulatory-toxicology testing methods. He is a national delegate for OECD (incl. WNT Working Group of National Coordinators of the Testing Guidelines programme) and EU (PARERE Preliminary Analysis of Regulatory Relevance). He also contributes to Expert Groups of EFSA in the field of developmental neurotoxicity regulatory-toxicology hazard and to the European risk assessments for biocides for the national competent authorities.

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Parra Morte

Juan Parra Morte

European Food Safety Authority (EFSA), Italy

Juan Parra Morte is a Toxicologist in the Pesticide Peer Review Unit of EFSA since 2008. He has been actively involved on the assessment of metabolites and impurities, including the EFSA PPR Guidance on Residue Definition, EFSA outsource projects on QSAR and Read-Across for the genotoxicity of metabolites, EFSA PPR Opinion on Comparative In Vitro Metabolism and ongoing revision of OECD Guidance on Residue Definition. He has also involved as lead toxicologist for the implantation of IUCLID and MetaPath, in the context of electronic submission of toxicology studies including metabolism studies for pesticides.

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Pelkonen

Olavi Pelkonen

University of Oulu, Finland

Olavi Pelkonen has been a Professor Emeritus for Pharmacology at the University of Oulu, Finland, since 1978. In 1987 he took on the full professorship for pharmacology. From 1978 to 2010 he has been the Head of the Department of Pharmacology and Toxicology. He has and had expert roles at EURL-ECVAM, OECD, WHO and EMA and joined the EFSA PPR Panel in 2015. His current interests include the development of in vitro and in silico approaches for drug development and chemical risk assessment, including also environmental risks.

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Venue

Online Conference | Die Akademie Fresenius GmbH
This conference is going to be held online.
Your Hotline for technical questions:
Phone: +49 231 75896-50
E-Mail: infoakademie-fresenius.de
www.akademie-fresenius.de

Prices & Services

Participation Fee: € 895.00 plus VAT.

The registration fee includes the following benefits:

  • Participation in the Online Conference
  • Conference documentation (available after the conference via download from our website)

Representatives of an authority or a public university are therefore eligible for a reduced fee of € 495.00 plus VAT per person (please provide evidence). The reduced fee cannot be combined with other rebates. 

Group reductions

For joint bookings received from one company we grant a 15% discount from the third participant onwards (it doesn’t apply for representatives of an authority or a public university). 

Event Documentation

Would you have liked to attend this conference, but cannot spare the time? 

For the price of € 295.00 plus VAT you can order a complete set of event documentation. A few days after the online conference you will receive the access data for the restricted download section of our website. There you will find all the latest versions of the presentations (subject to the approval of our speakers) as pdf-files in colour and in digital form. 

If you are interested, please send an e-mail to infoakademie-fresenius.de 


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Sabine Mummenbrauer

Your Contact

Sabine Mummenbrauer
Programme and conceptual design

+49 231 75896-82
smummenbrauerakademie-fresenius.de

Sabine Mummenbrauer

Your Contact

Sabine Mummenbrauer
Programme and conceptual design

+49 231 75896-82
smummenbrauerakademie-fresenius.de

Sabine Mummenbrauer

Your Contact

Sabine Mummenbrauer
Programme and conceptual design

+49 231 75896-82
smummenbrauerakademie-fresenius.de

Danielle Sörries

Your Contact

Danielle Sörries
Organisation and participant management

+49 231 75896-74
dsoerriesakademie-fresenius.de

Danielle Sörries

Your Contact

Danielle Sörries
Organisation and participant management

+49 231 75896-74
dsoerriesakademie-fresenius.de

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You can personally present your products and services directly to your specific target group. We would be happy to provide you with further information (without further obligation) on our range of available options – from displaying company information at the reception counter to including a supplement with information on your product portfolio in the event documentation package.

We would be pleased to assist you personally:

Analisa Mills

Analisa Mills
Phone: +49 231 75896-77
amillsakademie-fresenius.de

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We offer journalists and editors a platform where they can get in touch with the experts.

If you are the editor of a specialist publication and interested in a press pass or media partnership, please contact us well in advance. We would be pleased to send you our press bulletin as well as photographic materials where available as soon as the event is over.

Please contact us:

Katharina Geraridis

Katharina Geraridis
Phone: +49 231 75896-67
presseakademie-fresenius.de

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